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Information
P110 P110 is a dynamin-related protein 1 (Drp1) -specific inhibitor that binds directly to Drp1.
Targets
Drp1
In vitro
P110 is a Drp1-specific inhibitor that binds directly to Drp1. In some cases, this binding inhibits translocation to the mitochondria or prevents mitochondrial docking.
In vivo
P110 treatment inhibits the interaction of fission proteins Fis1/Drp1, decreases mitochondrial fission, and improves bioenergetics in three different rat models of IR, including primary cardiomyocytes, ex vivo heart model, and an in vivo myocardial infarction model.
Cell Research(from reference)
Cell lines:Primary cardiac myocytes
Concentrations:1 μmol/L
Incubation Time:2h + 2 to 60 min