计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC 50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity.
In Vitro
PD-1/PD-L1-IN-29(S4-1) (10 or 20 μM, 48 h) can increase the cytotoxicity of PBMCs against A375 tumor cells by blocking PD-1/PD-L1 interaction and restoring the activation state of PBMCs, with little direct killing effect on tumor cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PD-1/PD-L1-IN-29(S4-1)(10 or 25 mg/kg, i.p., 12 days) significantly inhibits tumour growth in the MC38 colorectal tumour mouse model, as observed in both the low and high dose groups (10 and 25 mg/kg), with inhibition rates of 65.9% and 88.8% respectively . The pharmacokinetic parameters of PD-1/PD-L1-IN-29(S4-1) in mice Parameters iv (5 mg/kg) po (50 mg/kg) T 1/2 (h) 9.78 4.77 T max (h) 0.08 0.92 C max (ng/mL) 6290 260.67 AUC 0-t (h*ng/mL) 3466.58/td> 808.04 AUC 0-∞ (h*ng/mL) 3566.62 830.34 CL (mL/h/kg) 1404.22 - MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
规格
英文名称
PD-1/PD-L1-IN-29
生化机理
PD-1/PD-L1-IN-29 (S4-1) 是一种强效的 PD-1/PD-L1 抑制剂，其 IC 50 值为 6.1 nM。PD-1/PD-L1-IN-29 可与 PD-L1 结合并破坏 PD-1/PD-L1 的相互作用，诱导 PD-L1 二聚化和内化，改善其在内质网的定位。
储存条件
-20°C储存
运输条件
超低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
分子量
460.48
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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