| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P656549-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | PF-06291874 |
| 生化机理 | PF-06291874 是一种高效、非肽类口服活性 Glukagon 受体拮抗剂。PF-06291874 正在进行 2 型糖尿病（T2DM）的研究。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | 胰高血糖素受体拮抗剂 |
| 产品介绍 |
PF-06291874 is a highly potent, non-peptide and orally active Glukagon receptor antagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM). In Vivo PF-06291874 exposure is approximately dose-proportional with a half-life of ∼19.7-22.7 h. PF-06291874 has a fast on and off rate. PF-06291874 is highly bound to human plasma protein, with a mean free fraction of ∼0.55%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCCC(C1=CC=C(C=C1)C(=O)NCCC(=O)O)OC2=CC(=C(C(=C2)C)N3C=C(C=N3)C(F)(F)F)C |
| 分子量 | 503.51 |
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