RAF-IN-1 is a potent b/cRAF inhibitor with an IC 50 s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAF wt , and bRAF V600E. RAF-IN-1 shows cell growth inhibition with GI 50 s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAF V600E mutation, respectively.