RORγt modulator 2 (Compound 21) is a modulator of retinoid-related orphan receptor γt ( RORγt ) with the IC 50 of <50 nM. RORγt modulator 2 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.