| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R408011-1ml |
1ml |
现货  |
|
| 英文别名 | (Z)-5-(quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Ro-3306 |
| 生化机理 | RO-3306 是一种 ATP 竞争性和选择性 CDK1 抑制剂，Ki为 20 nM，对多种人类激酶的选择性大于 15 倍。RO-3306 可增强 p53 介导的 Bax 激活和线粒体凋亡。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 细胞周期蛋白依赖性激酶 1 抑制剂；细胞周期蛋白依赖性激酶 2 抑制剂；细胞周期蛋白依赖性激酶 5 抑制剂 |
| 产品介绍 |
储存在-20℃。存放在干燥的条件下。该产品最多可存储12个月。 Information Ro-3306 RO-3306 is an ATP-competitive, and selective CDK1 inhibitor with K i of 20 nM, >15-fold selectivity against a diverse panel of human kinases. RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis . RO-3306 inhibits CDK1/cyclin B1, CDK1/cyclin A, CDK2/cyclin E, and CDK4/cyclin D activity with Ki of 35 nM, 110 nM, 340 nM, and over 2000 nM, respectively. Treatment of HCT116, SW480, and HeLa cells with RO-3306 for 20 h leads to a complete block of the cell cycle in the G2/M phase. The proliferation of both HCT116 and SW480 is effectively blocked by RO-3306. RO-3306 appears to be more proapoptotic in cancer cells (HCT116 and SW480) than nontumorigenic cells (MCF 10A and MCF 12A). RO-3306 effectively arrests oocyte maturation at a concentration of 10 μM. In vivo
cell lines：MM cell lines, patient MM cells, and PBMCs Concentrations：20 μM Incubation Time：72 h Powder Purity:≥98% |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | O=C1N=C(NCC2=CC=CS2)S\C1=C/C3=CC=C4N=CC=CC4=C3 |
| 分子量 | 351.45 |
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Appearance(Light yellow liquid) | pass |
| Record the entire process by video | Conform |
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