计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
Information
Ropinirole (SKF-101468A) a selectivedopamine D2 receptorsagonist withKiof 29 nM.
In vitro
Ropinirole scavenges free radicals and suppresses lipid peroxidation in the Fe2+–H2O2 reaction system.
In vivo
Ropinirole (50 mg/kg, i.p.) causes biphasic spontaneous locomotor activity in mice. Ropinirole (0.05-1.0 mg/kg SC) dose-dependently inhibits the dyskinesias induced by 2-di-n-propylamino-5,6-di-hydroxytetralin in mice. Ropirtirole, at doses of 1 and 10 μg, injected unilaterally directly into the striatum of the rat causes marked, contralateral (away from the side of injection) asymmetry and circling in mice. Ropinirole (0.05-1.0 mg/kg SC or 0.1 mg/kg PO) reverses all motor and behavioural deficits induced by MPTP in marmosets. Ropinirole (2 mg/kg, i.p.) for 7 days increases GSH, catalase and SOD activities in the striatum and protected striatal dopaminergic neurons against 6-hydroxydopamine (6-OHDA) in mice. Ropinirole (0.2 mg/kg, i.p.) improves the use of previously akinetic forelimb and produced robust circling behavior in lesioned rats with striatal over-expression of both D2R and D3R compared to lesioned animals that received blank vector. The subtherapeutic dose of ropinirole generates only modest motor effects in lesioned rats with sole over-expression of D2R or D3R. Ropinirole (1-8 mg t.i.d.) is rapidly and completely absorbed with oral bioavailability of 55%, clearance of 780 mL/min, elimination half-life of 6 hours in healthy volunteer. Since the major route of elimination for Ropinirole is by the CYP enzyme system, mainly by CYP1A2 and also by CYP3A4, inhibition of the former and possibly the latter may reduce the agent’s clearance and lead to drug accumulation. Ropinirole (0.25 mg-4.0 mg per day) treatment significantly improves patients\' ability to initiate sleep, the amount of stage 2 sleep and sleep adequacy compared with placebo. Periodic limb movements with arousal per hour decreases from 7.0 to 2.5 with ropinirole but increases from 4.2 to 6.0 with placebo. Periodic limb movements while awake per hour decreases from 56.5 to 23.6 with ropinirole but increases from 46.6 to 56.1 with placebo.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
SKF-101468A | 4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride
规格或纯度
10mM in DMSO
英文名称
Ropinirole HCl
生化机理
罗匹尼罗（SKF-101468A）是一种选择性多巴胺 D2 受体激动剂，Ki为 29 nM。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
作用机制
D2 类多巴胺受体激动剂
名称和识别符
EC号
635-615-9
分子类型
小分子
Isomeric SMILES
CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1.Cl
PubChem CID
分子量
296.84
技术文档
高级数据
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 35 mg/mL (200.93 mM); Ethanol: 35 mg/mL (200.93 mM); Water: Insoluble;
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
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