吴茱萸次碱

COX-2 Selective Inhibitors

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货号 (SKU)	包装规格	是否现货	价格	数量
R408599-1ml	1ml	现货

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Compound libraries (12332)

基本描述

英文别名	Rutecarpine \| Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-
规格或纯度	10mM in DMSO
英文名称	Rutaecarpine
生化机理	鲁替卡品（Rutaecarpine）是一种吲哚吡啶喹唑啉酮生物碱，从鲁替卡品（Evodia rutaecarpa）和相关草药中分离出来，是一种新型 COX-2 抑制剂。
储存温度	-80℃储存
运输条件	超低温冰袋运输
产品介绍	溶于DMSO，不溶于水。 Information Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class ofCOX-2inhibitor. In vitro Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. In vivo LD50: Mice 65mg/kg (i.v.). Cell Data cell lines：Ba/F3 cells and primary Ph⁺ leukemia cells Concentrations： Incubation Time： Powder Purity:≥99%

CYP1A2 Tchem 细胞色素 P450 1A2(Cytochrome P450 1A2) (2 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CYP1B1 Tchem 细胞色素 P450 1B1(Cytochrome P450 1B1) (2 活性数据)

点击查看靶蛋白信息： CYP1B1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

PTGS2 Tclin 前列腺素 G/H 合酶 2(Prostaglandin G/H synthase 2) (2 活性数据)

点击查看靶蛋白信息： PTGS2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CYP1A1 Tchem 细胞色素 P450 1A1(Cytochrome P450 1A1) (1 活性数据)

点击查看靶蛋白信息： CYP1A1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

溶解性	Solubility (25°C) In vitro DMSO: 32 mg/mL (96.28 mM); Water: Insoluble; Ethanol: Insoluble;

Concentration(Compounding value)	9.0-11.0(mmol/L)
Record the entire process by video	Conform

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guangbo Ge. (2023) Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors. CHEMICO-BIOLOGICAL INTERACTIONS, 378 (110501). [PMID:37080375] [10.1016/j.cbi.2023.110501]
2. Lushan Yu, Zhangting Wang, Minmin Huang, Yingying Li, Kui Zeng, Jinxiu Lei, Haihong Hu, Baian Chen, Jing Lu, Wen Xie, Su Zeng. (2016) Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1859 (1100). [PMID:26455953] [10.1016/j.bbagrm.2015.10.001]
3. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004]

1. Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guangbo Ge. (2023) Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors. CHEMICO-BIOLOGICAL INTERACTIONS, 378 (110501). [PMID:37080375] [10.1016/j.cbi.2023.110501]
2. Lushan Yu, Zhangting Wang, Minmin Huang, Yingying Li, Kui Zeng, Jinxiu Lei, Haihong Hu, Baian Chen, Jing Lu, Wen Xie, Su Zeng. (2016) Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1859 (1100). [PMID:26455953] [10.1016/j.bbagrm.2015.10.001]
3. Junyan Wang, Minmin Huang, Haihong Hu, Lushan Yu, Su Zeng. (2014) Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs. FOOD CHEMISTRY, 164 (74). [PMID:24996308] [10.1016/j.foodchem.2014.05.004]