| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R425883-1ml |
1ml |
现货  |
|
| 英文别名 | Rhynchophylline | Mitrinermine | Rhyncophylline | Rhynchophyllin | 76-66-4 | Mitrinermin | Rhynocophylline | UNII-46BQ79VJ8D | 46BQ79VJ8D | NSC 21731 | CHEMBL519266 | CHEBI:70069 | DTXSID70878612 | NSC-21731 | Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Rhynchophylline |
| 生化机理 | Ca 2+通道阻滞剂。非竞争性NMDA拮抗剂（IC 50 = 43.2μM）。抑制谷氨酸诱导的神经元死亡。抑制多巴胺诱导的细胞凋亡。减少内皮素诱导的脑小动脉收缩。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
溶于氯仿、丙酮、乙醇、苯，微溶于乙醚和醋酸乙酯，几乎不溶于石油醚。 |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | methyl (E)-2-[(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate |
| INCHI | InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1 |
| InChi Key | DAXYUDFNWXHGBE-KAXDATADSA-N |
| Canonical SMILES | CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O |
| Isomeric SMILES | CC[C@H]1CN2CC[C@]3([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)C4=CC=CC=C4NC3=O |
| PubChem CID | 5281408 |
| 分子量 | 384.47 |
| 熔点 | 216°C |
|---|---|
| 分子量 | 384.500 g/mol |
| XLogP3 | 2.300 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 384.205 Da |
| 单同位素质量Monoisotopic Mass | 384.205 Da |
| 拓扑极表面积Topological Polar Surface Area | 67.900 Ų |
| 重原子数Heavy Atom Count | 28 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 663.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H300: 吞咽致命 |
| 预防措施声明 |
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 |
| 1. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou. (2019) Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro. Experimental and Therapeutic Medicine, 17 (1): (251-259). [PMID:30651790] [10.3892/etm.2018.6909] |
| 1. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou. (2019) Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro. Experimental and Therapeutic Medicine, 17 (1): (251-259). [PMID:30651790] [10.3892/etm.2018.6909] |
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