计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Rilematovir (JNJ-678) 是一种融合蛋白抑制剂，具有抗病毒活性和低细胞毒性。 Rilematovir 可用于呼吸道合胞病毒治疗的研究。
Rilematovir (JNJ-678) is a novel fusion protein inhibitor. Rilematovir has the potential for respiratory syncytial virus (RSV) research.
In Vitro
Rilematovir is a small-molecule respiratory syncytial virus (RSV) fusion inhibitor currently under clinical evaluation in infants hospitalized for RSV infection. Rilematovir binds to RSV F protein in its prefusion conformation. Rilematovir displays very potent antiviral activity and low cytotoxicity. In addition to its activity against the RSV A2 strain, Rilematovir is also highly active against a number of RSV strains from both A and B subtypes. The EC 50 in an RSV infection assay using HeLa cells is 460 pM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Oral treatment of neonatal lambs with Rilematovir, or with an equally active close analog, efficiently inhibits established acute lower respiratory tract infection in the animals, even when treatment is delayed until external signs of respiratory syncytial virus illness have become visible . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:Fusion protein
规格
别名
利美托韦
规格或纯度
10mM in DMSO
英文名称
Rilematovir
生化机理
Rilematovir (JNJ-678) 是一种新型融合蛋白抑制剂。Rilematovir 具有研究呼吸道合胞病毒（RSV）的潜力。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
作用机制
融合糖蛋白 F0 抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
CS(=O)(=O)CCCN1C2=C(C=C(C=C2)Cl)C=C1CN3C4=C(C=CN=C4)N(C3=O)CC(F)(F)F
关联CAS
PubChem CID
MeSH Entry Terms
JNJ-53718678
分子量
500.92
技术文档
高级数据
产品属性
| ALogP | 2.9 |
|---|
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）