计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects
In Vitro
Ro 24-7429 (0.1-5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner. ?\nRo 24-7429 (1-25 μM) also induces apoptosis and inhibits antigen-induced lymphocyte proliferation. ?\nRo24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Peripheral blood mononuclear cells (PBMCs) Concentration: 0.1 μM, 1 μM, 5 μM Incubation Time: 3 days Result: Induced a dose-dependent increase in apoptosis of cultured PBMCs.
In Vivo
Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6J male and female mice (aged 6 to 8 weeks) induced by BleomycinDosage: 17.5 mg/kg, 35 mg/kg, and 70 mg/kg Administration: i.p.; daily; for 14 or 21 days Result: Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.
IC50& Target:HIV-1
规格
规格或纯度
10mM in DMSO
英文名称
Ro24-7429
生化机理
Ro24-7429 是一种强效的口服活性 HIV-1 转录活化蛋白 Tat 拮抗剂。Ro24-7429 还是一种 RUNT 相关转录因子 1 (RUNX1) 抑制剂。Ro24-7429 具有抗 HIV、抗纤维化和抗炎作用。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
拮抗剂
作用机制
人类免疫缺陷病毒 1 型 Tat 蛋白拮抗剂
名称和识别符
分子类型
小分子
分子量
272.73
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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