IL-31, 白细胞介素-31 受体激动剂

功能和特点
有货

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
rp174304-500μg
500μg 期货 Stock Image
rp174304-1mg
1mg 期货 Stock Image

基本描述

产品名称 IL-31, 白细胞介素-31 受体激动剂
别名 interleukin-31
英文别名 interleukin-31
规格或纯度 Moligand™
作用类型 激动剂
作用机制 白细胞介素-31 受体激动剂

AI解读

关联靶点(人)

IL31RA Tbio 白细胞介素-31受体亚基α(Interleukin-31 receptor subunit alpha) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
OSMR Tbio 制瘤素M特异性受体亚基β(Oncostatin-M-specific receptor subunit beta) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

产品规格参数

CAS编号和信息 rp174304

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

参考文献

1. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J et al..  (2006)  IL-31: a new link between T cells and pruritus in atopic skin inflammation..  J Allergy Clin Immunol,  117  (2): (411-7).  [PMID:16461142] [10.1021/op500134e]
2. Lee CH, Yu HS.  (2011)  Biomarkers for itch and disease severity in atopic dermatitis..  Curr Probl Dermatol,  41  (13): (136-48).  [PMID:21576954] [10.1021/op500134e]
3. Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B.  (2012)  Signaling by IL-31 and functional consequences..  Eur J Cell Biol,  91  (6-7): (552-66).  [PMID:21982586] [10.1021/op500134e]
4. Kim S, Kim HJ, Yang HS, Kim E, Huh IS, Yang JM.  (2011)  IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis..  Ann Dermatol,  23  (4): (468-73).  [PMID:22148014] [10.1021/op500134e]
5. Baron JM, Lüscher B.  (2012)  IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis..  Acta Derm Venereol,  92  (1): (5-6).  [PMID:22215012] [10.1021/op500134e]
6. Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC et al..  (2017)  Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody..  J Eur Acad Dermatol Venereol,  31  (1): (142-150).  [PMID:27501029] [10.1021/op500134e]
7. Storan ER, O'Gorman SM, McDonald ID, Steinhoff M.  (2015)  Role of cytokines and chemokines in itch..  Handb Exp Pharmacol,  226  (13): (163-76).  [PMID:25861779] [10.1021/op500134e]
8. Nemoto O, Furue M, Nakagawa H, Shiramoto M, Hanada R, Matsuki S, Imayama S, Kato M, Hasebe I, Taira K et al..  (2016)  The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study..  Br J Dermatol,  174  (2): (296-304).  [PMID:26409172] [10.1021/op500134e]

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