计算溶液所需的质量、体积或浓度。
活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
---|
货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
---|---|---|---|---|
rp174304-500μg |
500μg |
期货 ![]() |
| |
rp174304-1mg |
1mg |
期货 ![]() |
|
产品名称 | IL-31, 白细胞介素-31 受体激动剂 |
---|---|
别名 | interleukin-31 |
英文别名 | interleukin-31 |
规格或纯度 | Moligand™ |
作用类型 | 激动剂 |
作用机制 | 白细胞介素-31 受体激动剂 |
CAS编号和信息 | rp174304 |
---|
1. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J et al.. (2006) IL-31: a new link between T cells and pruritus in atopic skin inflammation.. J Allergy Clin Immunol, 117 (2): (411-7). [PMID:16461142] [10.1021/op500134e] |
2. Lee CH, Yu HS. (2011) Biomarkers for itch and disease severity in atopic dermatitis.. Curr Probl Dermatol, 41 (13): (136-48). [PMID:21576954] [10.1021/op500134e] |
3. Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B. (2012) Signaling by IL-31 and functional consequences.. Eur J Cell Biol, 91 (6-7): (552-66). [PMID:21982586] [10.1021/op500134e] |
4. Kim S, Kim HJ, Yang HS, Kim E, Huh IS, Yang JM. (2011) IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis.. Ann Dermatol, 23 (4): (468-73). [PMID:22148014] [10.1021/op500134e] |
5. Baron JM, Lüscher B. (2012) IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis.. Acta Derm Venereol, 92 (1): (5-6). [PMID:22215012] [10.1021/op500134e] |
6. Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC et al.. (2017) Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody.. J Eur Acad Dermatol Venereol, 31 (1): (142-150). [PMID:27501029] [10.1021/op500134e] |
7. Storan ER, O'Gorman SM, McDonald ID, Steinhoff M. (2015) Role of cytokines and chemokines in itch.. Handb Exp Pharmacol, 226 (13): (163-76). [PMID:25861779] [10.1021/op500134e] |
8. Nemoto O, Furue M, Nakagawa H, Shiramoto M, Hanada R, Matsuki S, Imayama S, Kato M, Hasebe I, Taira K et al.. (2016) The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study.. Br J Dermatol, 174 (2): (296-304). [PMID:26409172] [10.1021/op500134e] |