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Recombinant Human VEGF-C Protein

货号: rp181290
COA
有货
级别和纯度: 无动物源 ? 无动物源（Animal Free）—— 不含动物源成分生产，降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。 生物活性 ? 生物活性级（Bioactive）—— 经验证在功能检测中保持生物活性。当分子须具有功能活性而不仅是纯度时使用。 ActiBioPure™ ? ActiBioPure™ —— 阿拉丁面向生物活性和重组产品的优质系列。当同时需要高纯度和保持生物活性时使用。 高性能 ? 高性能级 —— 纯度和性能特性经过优化。适用于普通等级无法满足的灵敏分析。 His标签 ? 组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。 expressed in HEK293; 见COA
Accession #
P49767
蛋白标签
C-10His
表达系统
HEK293
内毒素水平
<1.0 EU/μg
生物活性
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 8.3 ng/mL.
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规格
库存
价格
数量
10μg
rp181290-10μg
现货 Stock Image
¥599.90
50μg
rp181290-50μg
现货 Stock Image
¥1,799.90
100μg
rp181290-100μg
现货 Stock Image
¥2,799.90
1mg
rp181290-1mg
期货 Stock Image
¥14,299.90
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大包装询价 收藏夹
Recombinant Human VEGF-C Protein
规格 储存与运输 图片 技术文档 高级数据 质检证书（CoA,COO,BSE/TSE 和分析图谱) 溶液计算器
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为什么选择此级别

ActiBioPure™,His标签,无动物源,无载体,生物活性,高性能 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

规格

产品名称
Recombinant Human VEGF-C Protein
别名
重组人VEGF-C蛋白 | 重组人血管内皮生长因子C蛋白
英文别名
Vascular endothelial growth factor C | VEGF-C | Flt4 ligand | Vascular endothelial growth factor-related protein | Flt4-L | VRP | VEGFC
规格或纯度
无动物源, 无载体, 生物活性, ActiBioPure™, 高性能, His标签, expressed in HEK293; 见COA
生化机理
Vascular endothelial growth factor C (VEGF-C) and VEGF-D constitute a subfamily of the angiogenic VEGF angiogenic factors. VEGF-C is synthesized as a 58 kDa molecule that consists of a VEGF homolgy domain (VHD) flanked by N- and C-terminal propeptides. The proprotein undergoes covalent homodimerization and stepwise proteolytic processing to generate ligands with increasing affinity for VEGF R3/Flt-4. Fully processed VEGF-C containing just the 21 kDa VHD can additionally bind and activate VEGF R2/KDR/Flk-1. Fully processed human VEGF-C shares 98% amino acid sequence identity with mouse and rat VEGF-C. VEGF-C interactions with VEGF R3 are critical for lymphangiogenesis. VEGF-C and VEGF R3 are usually co-expressed at sites with lymphatic vessel sprouting, in the embryo, and in various pathological conditions. Over-expression of VEGF-C in tumor cells induces tumoral lymphatic hyperplasia, resulting in enhanced lymph flow and metastasis to regional lymph nodes. It also induces physiological and intratumoral neoangiogenesis and vessel sprouting through interactions with VEGF R2. Post-translational: Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
生物活性
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 8.3 ng/mL.
表达系统
HEK293
种属
人(Human)
氨基酸
103-227 aa
序列
MHLLGFFSVACSLLAAALLPGPREAPAAAAATEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRRHHHHHHHHHH
蛋白标签
C-10His
无载体
Yes
无动物源
Yes
来源
重组表达
预测分子量
15.4 kDa
SDS-PAGE
20.1-27.7 kDa, under reducing conditions; 25.1 & 27.6 & 32.2-40.6 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4
浓度
expressed in HEK293; 见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存 12个月；复溶后建议分装，避免反复冻融。
图片
Recombinant Human VEGF-C Protein (rp181290) - Protein Bioactivity 
Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 8.3 ng/mL.
Recombinant Human VEGF-C Protein (rp181290) - SDS-PAGE 
3 μg/lane of Recombinant Human VEGF-C Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 20.1-27.7 kDa under reducing conditions and 25.1 & 27.6 & 32.2-40.6 kDa under non-reducing conditions. Members of the VEGF family are typically antiparallel, cystine-knot polypeptide dimers that are covalently linked by two intermolecular disulfide bonds. In VEGF-C, this VEGF homology domain is flanked by C- and N-terminal propeptides that are sequentially cleaved, giving rise to VEGF homologs with distinct functions (PMID: 20145116).

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

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高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ26F0535790 分析证书 rp181290
ZJ26F0535789 分析证书 rp181290
ZJ26F0535788 分析证书 rp181290
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