SKLB70326 is a small molecule inhibitor of cell cycle progression, which has the activity of inducing G?/G? phase arrest and apoptosis in human hepatoma cells. SKLB70326 can inhibit the proliferation of human hepatoma cells, induce cell cycle arrest and apoptosis , and its mechanism is related to downregulating cyclin-dependent kinase ( CDK ) 2, CDK4 and CDK6 , while activating PARP , caspase-3 , caspase-9 and Bax , and downregulating Bcl-2.