(3S,5R)-Fluvastatin-d 6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. Fluvastatinis a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.