22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 ( FKBP12 ) with a DC 50 of 0.5 µM in a FBXO22 dependent manner. 22-SLF degrades other endogenous proteins, such as BRD4 and EML4-ALK fusion protein.(Pink: Ligand for target protein SLF ; Black: Linker ; Blue: Ligand for E3 ligase ).