SB-272183 is a selective 5-HT 1A , 5-HT 1B and 5-HT 1D receptor antagonist. In addition, SB-272183 is also a potent and selective ligand for 5-HT 1A , 5-HT 1B and 5-HT 1D receptors in human recombinant and native tissues with pK i values ??of 8.0, 8.1 and 8.7, respectively. SB-272183 can be used in antidepressant research.