SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases ( SIKs ) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10 , but down-regulates pro-inflammatory cytokine IL-12.SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model.