Scalaradial is an inhibitor for bee venom phospholipase A2 ( PLA2 ) and transient receptor potential melastatin 2 ( TRPM2 ) ion channels, with IC 50 of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK , by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA -induced release of Arachidonic acid in the mouse peritoneal macrophage.