Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete ( Saccharopolyspora spinosa ), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity.