Sob-AM2 is a potent substrate ( K m =1.3 μM) targeting fatty acid amide hydrolase ( FAAH ) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β ( TRβ ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice.