sEH inhibitor-12 (compound 34) is a sEH inhibitor with an IC 50 value of 0.7 μM. sEH inhibitor-12 inhibits the 5-lipoxygenase-activating protein ( FLAP )-mediated leukotriene ( LT ) biosynthesis with an IC 50 value of 2.9 μM. sEH inhibitor-12 can be used for the research of inflammation.