Sucunamostat hydrate (SCO-792) is an orally active and reversible enteropeptidase inhibitor with IC 50 s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase , respectively. Sucunamostat hydrate can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.