Sulodexide 是一种软胶囊剂型的糖胺聚糖混合物。Sulodexide 由低分子量肝素 (80%) 和硫酸皮肤素 (20%) 组成。Sulodexide 通过与抗凝血酶 III (AT III) 和肝素辅因子 II (HC II) 相互作用并抑制凝血酶形成而表现出抗血栓活性。Sulodexide 通过释放组织纤溶酶原激活剂 (tPA) 发挥促纤溶活性。Sulodexide 具有内皮保护和抗炎作用,可改善慢性静脉疾病。
Sulodexide is an orally active mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III ( AT III ) and heparin cofactor II ( HC II ), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease.