(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc is a conjugate of E3 ligase ligand and linker , consisting of (S,R,S)-AHPC and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.