SAR405838 -d 10 (MI-77301-d 10 ) is the deuterium labeled SAR405838. SAR405838 (MI-77301), an analog of MI-773, is a highly potent and selective MDM2-p53 interaction inhibitor. SAR405838 binds to MDM2 with a K i of 0.88 nM. SAR405838 induces apoptosis and has potent antitumor activity.