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固相萃取磁珠结合了固相萃取技术和磁性分离技术，可广泛应用于样品前处理，在环境监测污染物检测、药物分析中的代谢物提取、食品安全检测、毒素或残留农药提取等方面广泛应用。磁珠表面通过功能化处理修饰有特定的吸附官能团，可通过疏水、静电或特异性结合作用力选择性吸附目标物，样品准备快速简单，经外加磁场可方便快捷地分离，从而提高样品前处理的效率和效果。
阿拉丁提供1 μm 苯硼酸固相萃取磁珠，内核由聚苯乙烯和纳米氧化铁组成。表面修饰的苯硼酸是一种能够通过可逆的共价反应对顺式二羟基化合物比如核苷、儿茶酚、糖类、糖蛋白等进行特异性识别的独特分子。苯硼酸与顺式二醇形成可逆硼酸酯键共价反应的基本原理如图所示，在碱性条件下，硼酸发生烃基化，被OH⁻进攻后形成四面体结构的硼酸阴离子，而后与顺式二羟基化合物中的邻二羟基发生酯化反应，形成稳定的五元环或六元环。这种结合是可逆的，在酸性条件下，或被其他顺式二羟基化合物竞争性结合时，形成的五元环或六元环极易水解，复合物解离成原始的苯硼酸和顺式二羟基化合物，达到分离富集的目的。苯硼酸磁珠在分离富集、疾病诊断、适配体筛选、药物传递和生物传感等领域可以广泛应用。
图1：苯硼酸磁珠亲和原理
| 货号 | S1520789 | S1520791 |
| 产品名称 | 1 μm 苯硼酸固相萃取磁珠 | 1 μm 苯硼酸固相萃取磁珠（低非特异性） |
| 浓度 | 10 mg/mL | 10 mg/mL |
| 粒径 | 约1 μm | 约1 μm |
| 表面电位 | -25 mV 左右 | 30 mV 左右 |
| 磁含量 | 大约 35%-45% | 大约 35%-45% |
| 分散溶剂 | 纯水 | 纯水 |
注意事项
磁珠取用前应充分混匀，防止取用改变磁珠浓度，避免长时间超声对磁珠表面破坏。
Solid phase extraction magnetic beads combine solid phase extraction technology with magnetic separation technology, and are widely used in sample pretreatment across various applications, including environmental monitoring for pollutant detection, metabolite extraction in pharmaceutical analysis, food safety testing, and extraction of toxins or pesticide residues. The bead surface is functionalized with specific adsorption functional groups, enabling selective adsorption of target compounds through hydrophobic, electrostatic, or specific interactions. Sample preparation is rapid and straightforward, and the beads can be conveniently and quickly separated using an external magnetic field, thereby improving the efficiency and effectiveness of sample pretreatment.
Aladdin offers 1 μm Phenylboronic Acid Solid Phase Extraction Magnetic Beads. The core is composed of polystyrene and iron oxide nanoparticles. The surface-modified phenylboronic acid is a unique molecule capable of specifically recognizing cis-dihydroxy compounds such as nucleosides, catechols, sugars, and glycoproteins through reversible covalent reactions. The fundamental principle of the reversible boronate ester bond formation between phenylboronic acid and cis-diols is illustrated in the figure. Under alkaline conditions, boric acid undergoes hydroxylation, being attacked by OH⁻ to form a tetrahedral boronate anion, which then undergoes an esterification reaction with the vicinal dihydroxy groups of cis-dihydroxy compounds to form stable five-membered or six-membered rings. This binding is reversible. Under acidic conditions, or when competitively bound by other cis-dihydroxy compounds, the formed five-membered or six-membered rings are readily hydrolyzed, dissociating the complex back into the original phenylboronic acid and cis-dihydroxy compounds, thereby achieving separation and enrichment. Phenylboronic acid magnetic beads can be widely used in fields such as separation and enrichment, disease diagnosis, aptamer screening, drug delivery, and biosensing.
Figure 1: Affinity Principle of Phenylboronic Acid Magnetic Beads
| Cat. No | S1520789 | S1520791 |
| Product Name | 1 μm Phenylboric acid Solid Phase Magnetic Beads | 1 μm Phenylboric acid Solid Phase Magnetic Beads (Low Non-specificity) |
| Concentration | 10 mg/mL | 10 mg/mL |
| Particle Size | Approx. 1 μm | Approx. 1 μm |
| Surface Potential | Approx. -25 mV | Approx. 30 mV |
| Magnetic Content | Approx. 35%–45% | Approx. 35%–45% |
| Dispersion Solvent | Pure Water | Pure Water |
Precautions
Ensure the magnetic beads are thoroughly mixed before use to prevent changes in concentration during pipetting. Avoid prolonged ultrasonication, which may damage the bead surface.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ26F0434870 |
分析证书 | S1520789 |
| ZJ26F0434869 |
分析证书 | S1520789 |
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