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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
唾液酸是神经氨酸，广泛存在动物组织及微生物中,是细胞膜糖蛋白和糖脂的重要成份，位于细胞膜糖蛋白及糖脂末端，参与细胞表面多种生理功能。恶性肿瘤表面糖蛋白和糖脂的结构及含量发生明显变化，可使多量的 SA 从癌细胞表面脱落进入血液，使血清 SA 升高.其含量的测定对某些先天性代谢障碍及 Behcet 综合症的研究具有重要意义。SA 升高也是心血管疾病的危险因素之一。唾液酸受神经氨酸苷酶的作用，形成 N-乙酰神经氨酸，进而在N-乙酰神经醛缩酶的作用下生成丙酮酸和 N-乙酰甘露糖醇。丙酮酸在 NADH 存在下由乳酸脱氢酶（LDH）作用下生成乳酸和NAD⁺，通过测定 NADH 吸光度下降速率即可得到样品中唾液酸的浓度。
Sialic acid, also known as neuraminic acid, is widely present in animal tissues and microorganisms. It is an important component of glycoproteins and glycolipids on cell membranes, located at the terminal ends, and participates in various physiological functions on the cell surface. In malignant tumors, the structure and content of glycoproteins and glycolipids on the cell surface undergo significant changes, causing large amounts of sialic acid to detach from cancer cells and enter the bloodstream, leading to elevated serum sialic acid levels. Determination of sialic acid content is of great significance for the study of certain congenital metabolic disorders and Behcet syndrome. Elevated sialic acid is also one of the risk factors for cardiovascular diseases. Sialic acid is acted upon by neuraminidase to form N‑acetylneuraminic acid, which is then converted into pyruvate and N‑acetylmannosamine by N‑acetylneuraminate aldolase. Pyruvate is converted intoPhospholipids are hydrolyzed by phospholipase D to produce choline and phosphatidic acid. Choline is oxidized by choline oxidase to generate hydrogen peroxide, which reacts with 4‑aminoantipyrine and DAOS to form a blue dye. This dye has a maximum absorption peak at 600 nm, and the absorption intensity is proportional to the phospholipid content in the sample. lactate and NAD⁺ by lactate dehydrogenase (LDH) in the presence of NADH. The sialic acid concentration in the sample can be obtained by measuring the rate of decrease in NADH absorbance.
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