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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
低密度脂蛋白（LDL） 是血清蛋白之一，主要由肝脏合成，负责将胆固醇运送到外周组织细胞。LDL可进入动脉壁并携入胆固醇，还可被氧化为氧化低密度脂蛋白（ox-LDL）。当LDL（尤其是ox-LDL）过量时，其所携带的胆固醇易在动脉壁沉积，长期可导致动脉硬化，因此LDL被称为“坏的胆固醇”。LDL水平与冠心病发生及动脉粥样硬化损伤呈正相关，是脂类疾病分类与风险预测的重要指标。 该产品用于检测生物样本中LDL-C含量，检测原理如下： 1、沉淀分离：用沉淀剂分离血清中的低密度脂蛋白胆固醇。 2、水解反应：胆固醇酯酶催化胆固醇酯水解，生成游离胆固醇（FC）和游离脂肪酸（FFA），将胆固醇酯转化为FC。 3、氧化反应：胆固醇氧化酶催化FC氧化，生成Δ⁴-胆甾烯酮和过氧化氢（H₂O₂）。 4、显色反应：过氧化物酶催化H₂O₂氧化4-氨基安替比林和酚，生成红色醌类化合物，该产物在500 nm处具有特征吸收峰。
Low‑density lipoprotein (LDL) is one of the serum lipoproteins, primarily synthesized by the liver, and is responsible for transporting cholesterol to peripheral tissue cells. LDL can enter the arterial wall and carry cholesterol into it, and can also be oxidized to oxidized low‑density lipoprotein (ox‑LDL). When LDL (especially ox‑LDL) is present in excess, the cholesterol it carries tends to deposit on the arterial walls, eventually leading to atherosclerosis over time. Consequently, LDL is known as "bad cholesterol." LDL levels are positively correlated with the incidence of coronary heart disease and atherosclerotic damage, making it an important indicator for lipid disorder classification and risk prediction. This product is used for the determination of LDL‑C content in biological samples. The detection principle is as follows: ① Precipitation separation: A precipitating reagent is used to separate low‑density lipoprotein cholesterol from serum. ② Hydrolysis reaction: Cholesterol esterase catalyzes the hydrolysis of cholesteryl esters to free cholesterol (FC) and free fatty acids (FFA), converting cholesteryl esters into FC. ③ Oxidation reaction: Cholesterol oxidase catalyzes the oxidation of FC, generating Δ⁴‑cholestenone and hydrogen peroxide (H₂O₂). ④ Colorimetric reaction: Peroxidase catalyzes the oxidation of 4‑aminoantipyrine and phenol by H₂O₂, generating a red quinone compound. This product exhibits a characteristic absorption peak at 500 nm.
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