索利那辛琥珀酸盐, 肌卡因乙酰胆碱受体 M2 拮抗剂

mAChR Selective Inhibitors | Agonists | Antagonists | Modulators

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货号 (SKU)	包装规格	是否现货	价格	数量
S408550-1ml	1ml	现货

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Compound libraries (12332)

基本描述

英文别名	YM905 \| Butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)
规格或纯度	10mM in Water
英文名称	Solifenacin succinate
生化机理	琥珀酸索利那新（YM905）是一种解痉剂，属于抗心绞痛类药物。
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	拮抗剂
作用机制	肌卡因乙酰胆碱受体 M2 拮抗剂
产品介绍	Information Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class. In vitro Solifenacin succinate is a new muscarinic receptor antagonist developed for the treatment of overactive bladder. The affinity constants (pKi) of solifenacin for recombinant human muscarinic M1, M2 and M3 receptors are 7.6, 6.9 and 8.0, respectively. Hence, the muscarinic M3 receptor subtype selectivity of solifenacin over the muscarinic M2 receptor subtype is readily apparent, but is only marginal over the muscarinic M1 receptor subtype. In the same study, solifenacin and oxybutynin inhibit muscarinic M3 receptor-mediated intracellular Ca2+ mobilization in bladder smooth muscle cells isolated from guinea pigs and in submandibular gland cells isolated from mice. In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥99%

ALogP	0.635
Rotatable Bond	6

CHRM1 Tclin 毒蕈碱乙酰胆碱受体 M1(Muscarinic acetylcholine receptor M1) (1 活性数据)

点击查看靶蛋白信息： CHRM1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

分子类型	小分子
Canonical SMILES	OC(=O)CCC(O)=O.O=C(OC1CN2CCC1CC2)N3CCC4=C(C=CC=C4)C3C5=CC=CC=C5
分子量	480.55

溶解性	Solubility (25°C) In vitro DMSO: 59 mg/mL (197.5 mM); Water: 59 mg/mL (197.5 mM); Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	3
DMSO(mM) Max Solubility	6.24
Water(mg / mL) Max Solubility	96
Water(mM) Max Solubility	199.77