| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S420365-1ml |
1ml |
现货  |
|
| 别名 | N-[4-[(2-氨基-6-甲基-4-嘧啶基)氨基]苯基] -4-(4-喹啉基氨基)苯甲酰胺 |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | SGI 1027 |
| 生化机理 | DNA甲基转移酶抑制剂。抑制哺乳动物DNA甲基转移酶DNMT3B，DNMT3A和DNMT1（IC50值为7.5、8和12.5μM，以Poly（dl-dC）为底物）。通过减少CpG岛超甲基化来重新激活沉默的肿瘤抑制基因。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | DNA 甲基转移酶 1 抑制剂 |
| 产品介绍 |
SGI-1027 是 DNA 甲基转移酶 (DNMT) 抑制剂，对以 poly(dI-dC) 为底物的 DNMT3B，DNMT3A 和 DNMT1 的 IC50 值分别为 7.5 μM，8 μM 和 12.5 μM。 Application： SGI-1027 has been used as a DNA methyltransferase inhibitor to study its effects on gene expression during osteogenic differentiation. It has also been used as a DNA methyltransferase 3a inhibitor to study its effects on interleukin-6 (IL-6)-induced loss of forkhead box P3 (Foxp3) gene expression in B-lymphocyte-induced maturation protein 1 (Blimp1)-Treg cells. |
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| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide |
| INCHI | InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34) |
| InChi Key | QSYLKMKIVWJAAK-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54 |
| Isomeric SMILES | CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54 |
| PubChem CID | 24858111 |
| 分子量 | 461.52 |
| 分子量 | 461.500 g/mol |
|---|---|
| XLogP3 | 4.800 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 461.196 Da |
| 单同位素质量Monoisotopic Mass | 461.196 Da |
| 拓扑极表面积Topological Polar Surface Area | 118.000 Ų |
| 重原子数Heavy Atom Count | 35 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 676.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
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