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(S,R,S)-AHPC-C₆-PEG₃ -丁基叠氮化物
- CAS编号: 2300155-90-0
- 分子量: 757.98
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S463448-50mg |
50mg |
期货  |
|
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基本描述
| 英文别名 | (2S,4R)-1-((S)-22-Azido-2-(tert-butyl)-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Protein degrader building block for PROTAC research, Crosslinker−E3 Lig |
|---|---|
| 规格或纯度 | ≥95% |
| 英文名称 | (S,R,S)-AHPC-C₆-PEG₃-butyl azide |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Description Protein degrader builiding block (S,R,S)-AHPC-C6-PEG3-butyl azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
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名称和识别符
| Canonical SMILES | O=C(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)CCCCCOCCOCCOCCCCCCN=[N+]=[N-] |
|---|---|
| 分子量 | 757.98 |
化学和物理性质
| 闪点(℉) | Not applicable |
|---|---|
| 闪点(℃) | Not applicable |
安全和危险性（GHS）
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