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(S,R,S)-AHPC-C₆-PEG₁ -C₃-PEG₁-叠氮化丁基
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| S463558-50mg |
50mg |
期货  |
|
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基本描述
| 英文别名 | Protein degrader building block for PROTAC research, Crosslinker−E3 Ligase ligand conjugate, VH032 conjugate, (2S,4R)-1-((S)-2-(6-((5-((6-Azidohexyl)oxy)pentyl)oxy)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiaz |
|---|---|
| 规格或纯度 | ≥95% |
| 英文名称 | (S,R,S)-AHPC-C₆-PEG₁-C₃-PEG₁-butyl azide |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Description Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Description Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
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参考文献
| 1. Kedra Cyrus, Marie Wehenkel, Eun-Young Choi, Hyeong-Jun Han, Hyosung Lee, Hollie Swanson, Kyung-Bo Kim,. (2010-10-06) Impact of linker length on the activity of PROTACs.. Molecular bioSystems, 7 ((2)): ( 359-364 ). [PMID:20922213] |