计算溶液所需的质量、体积或浓度。
概述
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC 50 s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases
In Vitro
SGC-CK2-1 inhibits CSNK2A2 and CSNK2A1 with IC 50 s value of 2.3 and 4.2 nM. SGC-CK2-1 inhibits DYRK2 with the IC 50 value of 3.7 μM. SGC-CK2-1 inhibits blood U-937, MV4-11, MOLM-13, OCI-LY19, OCI-AML5 cells with IC 50 s of 120, 690, 750, 760 and 810 nM, respectively. SGC-CK2-1 inhibits Head/Neck Detroit562 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Lung NCI-H2286 cells with an IC 50 of 550 nM. SGC-CK2-1 inhibits Brain SK-N-MC cells with an IC 50 of 730 nM. SGC-CK2-1 inhibits Breast BT-20 cells with an IC 50 of 810 nM. SGC-CK2-1 inhibits Skin A375 cells with an IC 50 of 830 nM. SGC-CK2-1 inhibits Stomach SNU-1 cells with an IC 50 of 860 nM. SGC-CK2-1 inhibits Duodenum Hutu 80 cells with an IC 50 of 920 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:CK2α 36 nM (IC 50 ) CK2α' 16 nM (IC 50 )
规格
别名
胃癌CK2-1
规格或纯度
10mM in DMSO
英文名称
SGC-CK2-1
生化机理
SGC-CK2-1 是一种高效、具有 ATP 竞争性和细胞活性的 CK2 化学探针，对两种人类 CK2 同工酶都具有独有的选择性，在 nanoBRET 分析中，对 CK2α 和 CK2α′ 的 IC 50 s 分别为 36 和 16 nM。SGC-CK2-1可用于CK2α和CK2α′的研究。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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