计算溶液所需的质量、体积或浓度。
概述
SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.
Appearance:Solid
IC50& Target:Cereblon
In Vitro:SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC 50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:SJF620 hydrochloride has a super pharmacokinetic profile in mice (1mg/kg; i.v.) with the half life (t 1/2 ) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802. MCE has not independently confirmed the accuracy of the
Biological Activity:SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC 50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.
规格
别名
SJF620盐酸盐
英文名称
SJF620 hydrochloride
储存条件
避光,-20°C储存,充氩
运输条件
超低温运输
名称和识别符
分子类型
小分子
分子量
797.3
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
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溶液计算器
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