Tylvalosin -d 9 (Acetylisovaleryltylo?sin-d 9 ) is the deuterium labeled Tylvalosin. Tylvalosin is a third-generation macrolide , with anti-inflammatory property. Tylvalosin decreases the levels of IL-8 , IL-6 , IL-1β, PGE2, TNF-α and NO, and reduces the inflammatory cells recruitment and activation in mouse acute lung injury model.