TRK-IN-30 (Compound C11) is the inhibitor for tropomyosin receptor kinase ( TRK ) that inhibits TRKA , TRKB and TRKC and drug resistant mutant TRKA G595R with an IC 50 of 1.8, 0.98, 3.8, and 54 nM, respectively. TRK-IN-30 inhibits the activation of the downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 inhibits the colony formation and cell migration of Km-12, arrests the cell cycle at G0/G1 phase, and induces apoptosis in Km-12.