Thalidomide -azetidine-pyrrolidine-C-piperidine-C2-OH is a conjugate of E3 ligase ligand and linker , consisting of Thalidomide and the corresponding Linker. Thalidomide -azetidine-pyrrolidine-C-piperidine-C2-OH can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.