Thalidomide -O-C4H4-N(Me)-piperidine-boc is a conjugate of E3 ligase ligand and linker , consisting of Thalidomide and the corresponding Linker. Thalidomide -O-C4H4-N(Me)-piperidine-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.