TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein ( TSPO ) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera ( AUTAC ). AUTAC can bind the TSPO on the outer mitochondrial membrane (OMM) of mitochondria and degrades impaired mitochondria and proteins via mitophagy , and improves mitochondrial activity. TSPO Ligand-Linker Conjugates 1 can be used in mitochondrial dysfunction related research, including neurodegenerative diseases, cancer , and diabetes.