Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP -IN-1 inhibits PARP and tubulin with IC 50 s of 74 nM ( PARP1 ), 109 nM ( PARP2 ), and 1.4 μM ( Microtubule/Tubulin ), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase.