Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR ) and 17.8 nM (M2 mAChR ) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM).