Tyrosinase-IN-37 (Compound 3c) is an effective Tyrosinase inhibitor with an IC 50 of 1.02 μM, exhibiting 14 times the inhibitory effect of kojic acid (Kojic acid,), which has an IC 50 of 14.74 μM. Tyrosinase-IN-37 can effectively prevent the browning of Rosa roxburghii. Additionally, Tyrosinase-IN-37 can also inhibit browning that is not caused by Tyrosinase.