Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK ( IC 50 = 1.4, 1.8 nM, against TrkA , TrkA G595R , respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase ( Trk ) is a key agent target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease.