TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK ( TRK G595R IC 50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line ( IC 50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect ( IC 50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.