TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC 50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRK WT , TRK G595R and TRK G667C , respectively. TRK-IN-2 shows antiproliferative activity with IC 50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA WT , Ba/F3-ETV6-TRKB WT , Ba/F3-LMNA-TRK G595R and Ba/F3-LMNA-TRKA G667C , respectively.