TrimTAC1 is a PROTAC degrader that selectively targets the degradation of the multimeric protein Nucleoporin. TrimTAC1 is composed of PROTAC target protein ligand (red part) (+)-JQ-1 , E3 ligase ligand (blue part) Acepromazine-OTs and PROTAC linker (black part) tert-Butyl N-[3-(piperazin-1-yl)propyl]carbamate. Among them, its E3 ligase ligand + linker can form Acepromazine-1-Piperazinepropanamine.