TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.

Information

Tempol (4-Hydroxy-TEMPO) is a superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. Phase 2.
In vitro

Tempol (4-Hydroxy-TEMPO) is a stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Tempol Exhibits radio-protective and anti-proliferative properties. Tempol inhibits oxygen-dependent radiation-induced damage. ^[1] Tempol induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. ^[2]

In vivo

Tempol reduces oxidant stress-mediated renal dysfunction and injury in the rat. ^[3] Tempol prevents cerebral vessel remodeling in hypertensive rats. ^[4] Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. ^[5] Tempol restores mitochondrial and cardiac functions in TNFα-induced oxidative stress and reduces cardiac hypertrophy in chronic hypoxic rats. ^[6]
Cell Data

cell lines：

Concentrations：', 'Concentrations': '

0.05–1.6 mM

Incubation Time：

Powder Purity:

规格

别名

坦普尔

规格或纯度

10mM in DMSO

英文名称

Tempol

生化机理

膜可渗透的超氧化物清除剂。SOD模拟。减轻超氧阴离子和过亚硝酸盐引起的炎症。降低氧化应激。

储存条件

-80℃储存

运输条件

特低温运输

名称和识别符

EC号

218-760-9

分子类型

小分子

Isomeric SMILES

CC1(CC(CC(N1[O])(C)C)O)C

分子量

172.24

Beilstein号

1422990

Reaxy-Rn

11328213

高级数据

化学和物理性质

闪点(℉)

294.80℉

闪点(℃)

146℃

熔点

69-71°C

安全和危险性（GHS）

象形图

GHS07

信号词

警告

危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H302: 吞食有害

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

WGK Germany

RTECS

TN8991000

Merck Index

9141

个人防护装备

dust mask type N95 (US),Eyeshields,Gloves

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批号(Lot Number)	证书类型	货号
F2413009	分析证书	T407895

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目录：技术文章

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