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| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
延胡索乙素
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T423038-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 四氢帕马丁 |
|---|---|
| 英文别名 | tetrahydropalmatine | 2934-97-6 | Rotundine | 10097-84-4 | DL-Tetrahydropalmatine | ROTUNDINUM | corydalis B | Hyndarin | Tetrahydropalmatine, (+/-)- | CHEMBL187892 | 78F8583LNQ | 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline | 2,3,9,10-Tetrameth |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Tetrahydropalmatine |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
味略苦，遇光、热变黄。难溶于水、石油醚，易溶于乙醚、氯仿。盐酸盐和硫酸盐都溶于水。 |
关联靶点（人）
F3
Tclin
组织因子(Tissue factor)
(1 活性数据)
SIGMAR1
Tclin
Sigma 非阿片类细胞内受体 1(Sigma non-opioid intracellular receptor 1)
(1 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
TDP1
Tchem
Tyrosyl-DNA phosphodiesterase 1
(345557 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
关联靶点（其它种属）
Coagulation factor III (5 活性数据)
Sigmar1
Sigma opioid receptor (160 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline |
| INCHI | InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3 |
| InChi Key | AEQDJSLRWYMAQI-UHFFFAOYSA-N |
| Canonical SMILES | COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC |
| Isomeric SMILES | COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC |
| PubChem CID | 5417 |
| 分子量 | 355.427 |
化学和物理性质
| 熔点 | 150 °C |
|---|---|
| 分子量 | 355.400 g/mol |
| XLogP3 | 3.200 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 355.178 Da |
| 单同位素质量Monoisotopic Mass | 355.178 Da |
| 拓扑极表面积Topological Polar Surface Area | 40.200 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 475.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
技术规格说明书
| Concentration(Compounding value) | 9.0-11.0(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
| 1. Yifan Wang, Wen Zhu, Dandan Lu, Chuzhao Zhang, Yue Wang. (2021) Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation. INTERNATIONAL IMMUNOPHARMACOLOGY, 100 (108107). [PMID:34482265] [10.1016/j.intimp.2021.108107] |
| 2. Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou. (2018) Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study. MOLECULES, 23 (4): (714). [PMID:29561801] [10.3390/molecules23040714] |
| 3. Qinqin Wang, Lu Wang, Kai Sheng, Lina Zou, Gaiping Li, Baoxian Ye. (2016) A simple and sensitive method for determination of tetrahydropalmatine based on a new voltammetric sensor. TALANTA, 161 (238). [PMID:27769402] [10.1016/j.talanta.2016.08.044] |
| 4. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu. (2016) Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 125 (205). [PMID:27031576] [10.1016/j.jpba.2016.03.033] |
| 5. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu. (2016) Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase. TALANTA, 146 (442). [PMID:26695288] [10.1016/j.talanta.2015.09.009] |
| 6. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu. (2015) Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography. JOURNAL OF CHROMATOGRAPHY A, 1383 (58). [PMID:25627970] [10.1016/j.chroma.2015.01.017] |
参考文献
| 1. Yifan Wang, Wen Zhu, Dandan Lu, Chuzhao Zhang, Yue Wang. (2021) Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation. INTERNATIONAL IMMUNOPHARMACOLOGY, 100 (108107). [PMID:34482265] [10.1016/j.intimp.2021.108107] |
| 2. Weijuan Du, Lisha Jin, Liping Li, Wei Wang, Su Zeng, Huidi Jiang, Hui Zhou. (2018) Development and Validation of a HPLC-ESI-MS/MS Method for Simultaneous Quantification of Fourteen Alkaloids in Mouse Plasma after Oral Administration of the Extract of Corydalis yanhusuo Tuber: Application to Pharmacokinetic Study. MOLECULES, 23 (4): (714). [PMID:29561801] [10.3390/molecules23040714] |
| 3. Qinqin Wang, Lu Wang, Kai Sheng, Lina Zou, Gaiping Li, Baoxian Ye. (2016) A simple and sensitive method for determination of tetrahydropalmatine based on a new voltammetric sensor. TALANTA, 161 (238). [PMID:27769402] [10.1016/j.talanta.2016.08.044] |
| 4. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu. (2016) Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 125 (205). [PMID:27031576] [10.1016/j.jpba.2016.03.033] |
| 5. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu. (2016) Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase. TALANTA, 146 (442). [PMID:26695288] [10.1016/j.talanta.2015.09.009] |
| 6. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu. (2015) Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography. JOURNAL OF CHROMATOGRAPHY A, 1383 (58). [PMID:25627970] [10.1016/j.chroma.2015.01.017] |