TLR7/8 agonist 1

≥96%

CAS编号: 1258457-59-8
分子式: C₂₂H₂₅N₅
分子量: 359.5
PubChem编号: 52945312

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货号 (SKU)	包装规格	是否现货
T648840-5mg	5mg	期货
T648840-10mg	10mg	期货
T648840-25mg	25mg	期货
T648840-50mg	50mg	期货

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Immunology/Inflammation (1945) Toll-like Receptor (TLR) (147)

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基本描述

别名	TLR7/8 激动剂 1
规格或纯度	≥96%
英文名称	TLR7/8 agonist 1
生化机理	TLR7/8 激动剂 1 是一种收费样受体（TLR7）/ TLR8 双拮抗咪唑喹啉。
储存温度	避光,-80℃储存
运输条件	超低温冰袋运输
产品介绍	TLR7/8 agonist 1 is a toll-like receptor ( TLR7 )/ TLR8 dual-agonistic imidazoquinoline. In Vitro TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity.TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC 50 of 20 nM. TLR7/8 agonist 1 is covalently coupled directly to commercially-available fluorescein isothiocyanate and rhodamine B isothiocyanate. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Assay Fresh human peripheral blood mononuclear cells ( hPBMC ) are isolated from human blood obtained by venipuncture with informed consent and as per institutional guidelines on Ficoll–Hypaque gradients. Aliquots of PBMCs (10 5 cells in 100 μL/well) are stimulated for 12 h with graded concentrations of test compounds (e.g., TLR7/8 agonist 1; 0.1, 1, 10, and 100 μg/mL ). Supernatants are isolated by centrifugation and are assayed in duplicates using analyte-specific multiplexed cytokine/chemokine bead array assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:TLR7 TLR8

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关联靶点（人）

TLR8 Tchem Toll 类受体 8(Toll-like receptor 8) (1 活性数据)

点击查看靶蛋白信息： TLR8

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TLR7 Tclin Toll 类受体 7(Toll-like receptor 7) (2 活性数据)

点击查看靶蛋白信息： TLR7

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HEK293 (82097 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PBMC (10003 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Tlr7 Toll-like receptor 7 (174 活性数据)

点击查看靶蛋白信息： Tlr7

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IUPAC Name	1-[[4-(aminomethyl)phenyl]methyl]-2-butylimidazo[4,5-c]quinolin-4-amine
INCHI	InChI=1S/C22H25N5/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25)
InChi Key	SDSKFWHQCNBICO-UHFFFAOYSA-N
Canonical SMILES	CCCCC1=NC2=C(N1CC3=CC=C(C=C3)CN)C4=CC=CC=C4N=C2N
Isomeric SMILES	CCCCC1=NC2=C(N1CC3=CC=C(C=C3)CN)C4=CC=CC=C4N=C2N
PubChem CID	52945312
分子量	359.5

化学和物理性质

分子量	359.500 g/mol
XLogP3	3.500
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	6
精确质量Exact Mass	359.211 Da
单同位素质量Monoisotopic Mass	359.211 Da
拓扑极表面积Topological Polar Surface Area	82.800 Å²
重原子数Heavy Atom Count	27
形式电荷Formal Charge	0
复杂度Complexity	464.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1